DESCRIPTION
The goal of GENESIS is to analyze summary-level GWAS statistics and external linkage disequilibrium information to estimate common variants effect-size distributions, characterized by the proportion of underlying susceptibility SNPs and a flexible normal-mixture model for their effects.
DETAILS
This package allows flexibility by considering a 2- or 3-component model, which respectively incorporate a single normal, or a mixture of two normal distributions, for specifying the effects of non-null SNPs. This package also allows users to make predictions regarding yield of future GWAS with larger sample sizes.